Abstract
Background Perifascial areolar tissue (PAT) transplant is a technique in which a sheet of connective
tissue on the fascia is harvested and transplanted to the wound bed. PAT engraftment
fails when the exposed area of tendons, bones, or artificial materials is large. On
the other hand, combination of tissue transplant and basic fibroblast growth factor
(bFGF) improves the survival rate of the transplanted tissue.
Materials and Methods A wound model was created in which the artificial material was exposed on rats' backs.
All the rats underwent PAT transplant, but the rats were divided into two groups according
to the PAT processing method beforehand. In one group, the PAT was immersed in water
for injection before transplant (bFGF[–] group), and in the other group, the PAT was
immersed in bFGF product (bFGF[+] group). Specimens were collected 7 days after surgery
to assess the histologic thickness of the PAT and the gene expression in the PAT.
Results The thickness of the PAT in the tissue slices was significantly higher in the bFGF(+)
group than in the bFGF(–) group. Expressions of CD34 and COL3A1 were significantly
higher in the bFGF(+) group than in the bFGF(–) group.
Conclusion The results of this study indicate that adding bFGF to the PAT transplant may promote
PAT engraftment and wound healing by increasing angiogenesis and may increase granulation
formation, which may result in a stronger covering that prevents the prosthesis from
being exposed.
Keywords
perifascial areolar tissue - loose connective tissue - basic fibroblast growth factor
- ulcer
