Semin Reprod Med 2024; 42(01): 005-014
DOI: 10.1055/s-0044-1787687
Review Article

Role of Anti-Müllerian Hormone in Male Reproduction and Sperm Motility

Hamza Benderradji
1   Department of Endocrinology, Diabetology, and Metabolism, CHU Lille, Lille, France
2   Inserm, CHU Lille, Unit 1172, Lille Neuroscience & Cognition (LilNCog), University of Lille, Lille, France
3   Department of Andrology, Urology and Renal Transplantation, University of Lille, CHU Lille, Lille University Hospital, Lille, France
Julie Prasivoravong
3   Department of Andrology, Urology and Renal Transplantation, University of Lille, CHU Lille, Lille University Hospital, Lille, France
François Marcelli
3   Department of Andrology, Urology and Renal Transplantation, University of Lille, CHU Lille, Lille University Hospital, Lille, France
Clara Leroy
3   Department of Andrology, Urology and Renal Transplantation, University of Lille, CHU Lille, Lille University Hospital, Lille, France
4   Department of Pediatric Endocrinology, Reference Centre for Genital Development Abnormalities, University of Lille, CHU Lille, DevGen, Lille, France
› Author Affiliations
Funding This review did not receive any specific grants from any funding agency in the public, commercial, or nonprofit sectors.


Anti-Müllerian hormone (AMH) is secreted by Sertoli cells and is responsible for the regression of Müllerian ducts in the male fetus as part of the sexual differentiation process. Serum AMH concentrations are at their lowest levels in the first days after birth but increase after the first week, likely reflecting active Sertoli cell proliferation. AMH rises rapidly in concentration in boys during the first month, reaching a peak level at ∼6 months of age, and it remains high during childhood, then they will slowly decline during puberty, falling to low levels in adulthood. Serum AMH measurement is used by pediatric endocrinologist as a specific marker of immature Sertoli cell number and function during childhood. After puberty, AMH is released especially by the apical pole of the Sertoli cells toward the lumen of the seminiferous tubules, resulting in higher levels in the seminal plasma than in the serum. Recently, AMH has received increasing attention in research on male fertility–related disorders. This article reviews and summarizes the potential contribution of serum AMH measurement in different male fertility–related disorders.

Authors' Contributions

I confirm that all authors participated in writing the manuscript and have seen and approved the submitted version.

Publication History

Article published online:
24 June 2024

© 2024. Thieme. All rights reserved.

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