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CC BY 4.0 · Int Arch Otorhinolaryngol 2024; 28(03): e543-e551
DOI: 10.1055/s-0044-1787736
Systematic Review

Hearing Function after CyberKnife for Vestibular Schwannoma: A Systematic Review[*]

Matheus Pedrosa Tavares 
1   Postgraduate Program in Health Sciences, School of Medicine, Universidade de Brasília, Brasília, DF, Brazil
,
Fayez Bahmad Jr 
1   Postgraduate Program in Health Sciences, School of Medicine, Universidade de Brasília, Brasília, DF, Brazil
› Author Affiliations Funding The authors declare that they have received no funding from agencies in the public, private or non-profit sectors to conduct the present study.
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Abstract

Introduction CyberKnife (CK) radiosurgery is a treatment strategy for vestibular schwannoma (VS).

Objectives To evaluate hearing preservation (HP) after CK for VS.

Data Synthesis The study was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, and it was registered at the International Prospective Register of Systematic Reviews (PROSPERO, under number CRD42021250300). The inclusion criteria were based on the population, intervention, comparison, outcome, timing and study design (PICOTS) strategy: population – patients with VS; intervention – CK; Comparison – none; Outcome – serviceable HP defined by Gardner and Robertson as grades I or II, or by the American Academy of Otolaryngology and Head and Neck Surgery as classes A or B; timing – mean follow-up longer than 1 year; and study design – retrospective or prospective studies. The exclusion criteria were: studies not published in English; studies published before January 2000 and after October 2021; and studies only including patients with neurofibromatosis type 2 or submitted to a previous treatment. The PubMed/MEDLINE, EMBASE, Web of Science, Cochrane Library, LILACS, and IBECS databases were used and last searched on October 27th, 2021. Statistical heterogeneity was assessed using I 2 statistics. The appraisal checklist was used to assess the risk of bias in the included studies. A total of 222 studies were analyzed, and 13 were included in the synthesis, which represents 493 participants with serviceable hearing before intervention. The mean HP rate after CK using a random effects model was of 68% (95% confidence interval [95%CI]: 59–76%) at a mean follow-up of 42.96 months.

Conclusion The longer follow-up period was associated with a lower HP rate after CK radiosurgery for VS in the qualitative synthesis.

Keywords

vestibular schwannoma - radiosurgery - cyberKnife - hearing - systematic review - meta-analysis

* Paper presented at the 21st Congress of Fundação Otorrinolaringologia (FORL).




Publication History

Received: 08 October 2022

Accepted: 19 April 2023

Article published online:
05 July 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Marinelli JP, Lohse CM, Carlson ML. Incidence of Vestibular Schwannoma over the Past Half-Century: A Population-Based Study of Olmsted County, Minnesota. Otolaryngol Head Neck Surg 2018; 159 (04) 717-723 DOI: 10.1177/0194599818770629.
    CrossrefPubMedGoogle Scholar
  • 2 Marinelli JP, Grossardt BR, Lohse CM, Carlson ML. Prevalence of Sporadic Vestibular Schwannoma: Reconciling Temporal Bone, Radiologic, and Population-based Studies. Otol Neurotol 2019; 40 (03) 384-390 DOI: 10.1097/MAO.0000000000002110.
    CrossrefPubMedGoogle Scholar
  • 3 Reznitsky M, Petersen MMBS, West N, Stangerup SE, Cayé-Thomasen P. Epidemiology Of Vestibular Schwannomas - Prospective 40-Year Data From An Unselected National Cohort. Clin Epidemiol 2019; 11: 981-986 DOI: 10.2147/CLEP.S218670.
    CrossrefPubMedGoogle Scholar
  • 4 Evans DGR, Moran A, King A, Saeed S, Gurusinghe N, Ramsden R. Incidence of vestibular schwannoma and neurofibromatosis 2 in the North West of England over a 10-year period: higher incidence than previously thought. Otol Neurotol 2005; 26 (01) 93-97 DOI: 10.1097/00129492-200501000-00016.
    CrossrefPubMedGoogle Scholar
  • 5 Mohyuddin A, Neary WJ, Wallace A. et al. Molecular genetic analysis of the NF2 gene in young patients with unilateral vestibular schwannomas. J Med Genet 2002; 39 (05) 315-322 DOI: 10.1136/jmg.39.5.315.
    CrossrefPubMedGoogle Scholar
  • 6 Adler Jr JR, Chang SD, Murphy MJ, Doty J, Geis P, Hancock SL. The Cyberknife: a frameless robotic system for radiosurgery. Stereotact Funct Neurosurg 1997; 69 (1–4 Pt 2): 124-128 DOI: 10.1159/000099863.
    CrossrefPubMedGoogle Scholar
  • 7 Muzevic D, Legcevic J, Splavski B, Cayé-Thomasen P. Stereotactic radiotherapy for vestibular schwannoma. Cochrane Database Syst Rev 2014; (12) CD009897 DOI: 10.1002/14651858.CD009897.pub2.
    CrossrefPubMedGoogle Scholar
  • 8 Coughlin AR, Willman TJ, Gubbels SP. Systematic Review of Hearing Preservation After Radiotherapy for Vestibular Schwannoma. Otol Neurotol 2018; 39 (03) 273-283 DOI: 10.1097/MAO.0000000000001672.
    CrossrefPubMedGoogle Scholar
  • 9 Carlson ML, Vivas EX, McCracken DJ. et al. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on Hearing Preservation Outcomes in Patients With Sporadic Vestibular Schwannomas. Neurosurgery 2018; 82 (02) E35-E39 DOI: 10.1093/neuros/nyx511.
    CrossrefPubMedGoogle Scholar
  • 10 Mahboubi H, Sahyouni R, Moshtaghi O. et al. CyberKnife for Treatment of Vestibular Schwannoma: A Meta-analysis. Otolaryngol Head Neck Surg 2017; 157 (01) 7-15
    CrossrefPubMedGoogle Scholar
  • 11 Page MJ, McKenzie JE, Bossuyt PM. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021; 372 (71) n71 DOI: 10.1136/bmj.n71.
    CrossrefPubMedGoogle Scholar
  • 12 Gardner G, Robertson JH. Hearing preservation in unilateral acoustic neuroma surgery. Ann Otol Rhinol Laryngol 1988; 97 (01) 55-66 DOI: 10.1177/000348948809700110.
    CrossrefPubMedGoogle Scholar
  • 13 Committee on Hearing and Equilibrium guidelines for the evaluation of hearing preservation in acoustic neuroma (vestibular schwannoma). American Academy of Otolaryngology-Head and Neck Surgery Foundation, INC. Otolaryngol Head Neck Surg 1995; 113 (03) 179-180 DOI: 10.1016/S0194-5998(95)70101-X.
    CrossrefPubMedGoogle Scholar
  • 14 Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327 (7414) 557-560 DOI: 10.1136/bmj.327.7414.557.
    CrossrefPubMedGoogle Scholar
  • 15 Ju DT, Lin JW, Lin MS. et al. Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2. Acta Neurochir Suppl (Wien) 2008; 101: 169-173 DOI: 10.1007/978-3-211-78205-7_29.
    CrossrefPubMedGoogle Scholar
  • 16 Mahadevan A, Floyd S, Wong E, Chen C, Kasper E. Clinical outcome after hypofractionated stereotactic radiotherapy (HSRT) for benign skull base tumors. Comput Aided Surg 2011; 16 (03) 112-120
    CrossrefPubMedGoogle Scholar
  • 17 Wagner JN, Glaser M, Wowra B. et al. Vestibular function and quality of life in vestibular schwannoma: does size matter?. Front Neurol 2011; 2: 55
    CrossrefPubMedGoogle Scholar
  • 18 Rueß D, Pöhlmann L, Grau S. et al. Long-term follow-up after stereotactic radiosurgery of intracanalicular acoustic neurinoma. Radiat Oncol 2017; 12 (01) 68
    CrossrefPubMedGoogle Scholar
  • 19 Wilson HP, Price PM, Ashkan K. et al. CyberKnife Radiosurgery of Skull-base Tumors: A UK Center Experience. Cureus 2018; 10 (03) e2380 DOI: 10.7759/cureus.2380.
    CrossrefPubMedGoogle Scholar
  • 20 Dutta D, Balaji Subramanian S, Murli V, Sudahar H, Gopalakrishna Kurup PG, Potharaju M. Dosimetric comparison of Linac-based (BrainLAB®) and robotic radiosurgery (CyberKnife ®) stereotactic system plans for acoustic schwannoma. J Neurooncol 2012; 106 (03) 637-642 DOI: 10.1007/s11060-011-0703-5.
    CrossrefPubMedGoogle Scholar
  • 21 Haidar YM, Bhatt JM, Ghavami Y. et al. Dosimetric Analysis of Neural and Vascular Structures in Skull Base Tumors Treated with Stereotactic Radiosurgery. Otolaryngol Head Neck Surg 2017; 156 (05) 857-862 DOI: 10.1177/0194599817691452.
    CrossrefPubMedGoogle Scholar
  • 22 Windisch P, Tonn JC, Fürweger C. et al. Longitudinal Changes of Quality of Life and Hearing Following Radiosurgery for Vestibular Schwannoma. Cancers (Basel) 2021; 13 (06) 1315 https://pubmed.ncbi.nlm.nih.gov/33804061/
    CrossrefPubMedGoogle Scholar
  • 23 Fatima N, Meola A, Ding VY. et al. The Stanford stereotactic radiosurgery experience on 7000 patients over 2 decades (1999–2018): looking far beyond the scalpel. J Neurosurg 2021; 135 (06) 1-17 DOI: 10.3171/2020.9.JNS201484.
    CrossrefPubMedGoogle Scholar
  • 24 Porter R. Hearing preservation in patients who have undergone cyberknife stereotactic radiosurgery for treatment of vestibular schwannoma. Acta Neurochir (Wien) 2011; 153 (09) 1845
    Google Scholar
  • 25 Ogino H, Shibamoto Y, Murai T. et al. Five-fraction CyberKnife Stereotactic Radiotherapy for Acoustic Neuroma: Evaluation of Three Different Dose Levels. Int J Radiat Oncol Biol Phys 2011; 81 (02) S286 DOI: 10.1016/j.ijrobp.2011.06.1752.
    CrossrefGoogle Scholar
  • 26 Wzietek I, Namysl-Kaletka A, Napieralska A, Gabrys D, Blamek S. Robotic radiosurgery for vestibular schwannomas-the early tumor response and treatment tolerance. Radiother Oncol 2016; 119: S495
    CrossrefGoogle Scholar
  • 27 Ruess D, Poehlmann L, Treuer H, Kocher M, Ruge MI. Clinical and radiological long term outcome of acoustic neuromas (Koos Grade I–IV) after stereotactic radiosurgery. Neuro-oncol 2016; 18: vi13
    CrossrefGoogle Scholar
  • 28 Daniel R, Poehlmann L, Treuer H. et al. Clinical and radiological outcome of vestibular schwannomas (Koos grade I - IV) after stereotactic radiosurgery. Neuro-oncol 2018; 20: iii312
    CrossrefGoogle Scholar
  • 29 Daniel R, Weyer V, Hoevels M. et al. Stereotactic radiosurgery of benign brain tumors in elderly patients: Evaluation of clinical outcome and toxicity. Neuro-oncol 2018; 20 (Suppl. 03) iii311-iii311 DOI: 10.1093/neuonc/noy139.364.
    CrossrefGoogle Scholar
  • 30 Malone S, Zheng J, Sinclair J. et al. Mature treatment results of 120 cases of acoustic neuroma treated with cyberknife at a single institution. Ann Oncol 2019; 30: v157
    CrossrefGoogle Scholar
  • 31 Gaviolli E, Zheng J, Sinclair J. et al. LONG TERM RESULTS OF 120 CASES OF VESTIBULAR SCHWANNOMA TREATED WITH CYBERKNIFETM ROBOTIC STEREOTACTIC RADIOSURGERY AT THE OTTAWA HOSPITAL CANCER CENTRE. Radiother Oncol 2019; 139: S16-S17
    CrossrefGoogle Scholar
  • 32 Naeem K, Porter R. Clinical Outcomes for Patients Undergoing Treatment for Vestibular Schwannoma with “Excellent Hearing. ” In: 2019. :s-0039–1679628. DOI: 10.1055/s-0039-1679628
    Article in Thieme ConnectGoogle Scholar
  • 33 Häußler S, Knopke S, Gräbel S, Kufeld M, Förster U, Olze H. Vestibular schwannoma and CI - a challenging indication with the possibility of hearing rehabilitation. In: 2020. :s-0040–1711101. DOI: 10.1055/s-0040-1711101
    Article in Thieme ConnectGoogle Scholar
  • 34 Fouad A, Tran ED, Feng AY. et al. Stereotactic Radiosurgery for Vestibular Schwannoma Outcomes in Patients With Perfect Word Recognition-A Retrospective Cohort Study. Otol Neurotol 2021; 42 (05) 755-764 https://pubmed.ncbi.nlm.nih.gov/33443977/
    CrossrefPubMedGoogle Scholar
  • 35 Combs SE, Engelhard C, Kopp C. et al. Long-term outcome after highly advanced single-dose or fractionated radiotherapy in patients with vestibular schwannomas - pooled results from 3 large German centers. Radiother Oncol 2015; 114 (03) 378-383
    CrossrefPubMedGoogle Scholar
  • 36 Rueß D, Pöhlmann L, Hellerbach A. et al. Acoustic Neuroma Treated with Stereotactic Radiosurgery: Follow-up of 335 Patients. World Neurosurg 2018; 116: e194-e202
    CrossrefPubMedGoogle Scholar
  • 37 Chang SD, Gibbs IC, Sakamoto GT, Lee E, Oyelese A, Adler Jr JR. Staged stereotactic irradiation for acoustic neuroma. Neurosurgery 2005; 56 (06) 1254-1261 , discussion 1261–1263
    CrossrefPubMedGoogle Scholar
  • 38 Sakamoto GT, Blevins N, Gibbs IC. Cyberknife radiotherapy for vestibular schwannoma. Otolaryngol Clin North Am 2009; 42 (04) 665-675 DOI: 10.1016/j.otc.2009.04.006.
    CrossrefPubMedGoogle Scholar
  • 39 Hayden Gephart MG, Hansasuta A, Balise RR. et al. Cochlea radiation dose correlates with hearing loss after stereotactic radiosurgery of vestibular schwannoma. World Neurosurg 2013; 80 (3–4): 359-363
    CrossrefPubMedGoogle Scholar
  • 40 Rashid A, Karam SD, Rashid B. et al. Multisession Radiosurgery for Hearing Preservation. Semin Radiat Oncol 2016; 26 (02) 105-111
    CrossrefPubMedGoogle Scholar
  • 41 Teo M, Zhang M, Li A. et al. The Outcome of Hypofractionated Stereotactic Radiosurgery for Large Vestibular Schwannomas. World Neurosurg 2016; 93: 398-409
    CrossrefPubMedGoogle Scholar
  • 42 Wowra B, Muacevic A, Fürweger C, Schichor C, Tonn JC. Therapeutic profile of single-fraction radiosurgery of vestibular schwannoma: unrelated malignancy predicts tumor control. Neuro-oncol 2012; 14 (07) 902-909
    CrossrefPubMedGoogle Scholar
  • 43 Kocak ME, Sengul A, Ekici K, Olmezoglu A, Seseogullari O. Fractionated stereotactic radiosurgery for vestibular schwannomas using cyberknife: A single institution experience. J Pak Med Assoc 2016; 66 (09) 1089-1093
    PubMedGoogle Scholar
  • 44 Jumeau R, Bondiau PY, Parietti-Winkler C. et al. Vestibular schwannomas treated with Cyberknife®: clinical outcomes. Tumori 2016; 102 (06) 569-573
    CrossrefPubMedGoogle Scholar
  • 45 Feng SW, Hsieh CC, Yang YJ, Chen YH, Tang CT, Ju DT. Hearing preservation after cyberknife stereotactic radiosurgery for vestibular schwannomas. J Med Sci 2019; 39 (01) 10-17
    CrossrefGoogle Scholar
  • 46 Wu CH, Chen CM, Cheng PW, Young YH. Acute sensorineural hearing loss in patients with vestibular schwannoma early after cyberknife radiosurgery. J Neurol Sci 2019; 399: 30-35
    CrossrefPubMedGoogle Scholar
  • 47 Berber T, Gunenc S, Aksaray F. et al. The Retrospective Evaluation of The Local Tumor Control and Adverse Effects of Treatment in Patients Treated Using Cyberknife Stereotactic Radiotherapy in Vestibular Schwannomas. J Acad Res Med-JAREM 2020; 10 (01) 10-15
    CrossrefGoogle Scholar
  • 48 Ishihara H, Saito K, Nishizaki T. et al. CyberKnife radiosurgery for vestibular schwannoma. Minim Invasive Neurosurg 2004; 47 (05) 290-293
    Article in Thieme ConnectPubMedGoogle Scholar
  • 49 Hansasuta A, Choi CYH, Gibbs IC. et al. Multisession stereotactic radiosurgery for vestibular schwannomas: single-institution experience with 383 cases. Neurosurgery 2011; 69 (06) 1200-1209
    CrossrefPubMedGoogle Scholar
  • 50 Karam SD, Tai A, Strohl A. et al. Frameless fractionated stereotactic radiosurgery for vestibular schwannomas: a single-institution experience. Front Oncol 2013; 3: 121
    CrossrefPubMedGoogle Scholar
  • 51 Lin MC, Chen CM, Tseng HM, Xiao F, Young YH. A proposed method to comprehensively define outcomes in acoustic tumor patients undergoing CyberKnife management. Stereotact Funct Neurosurg 2013; 91 (03) 177-185 DOI: 10.1159/000343215.
    CrossrefPubMedGoogle Scholar
  • 52 Morimoto M, Yoshioka Y, Kotsuma T. et al. Hypofractionated stereotactic radiation therapy in three to five fractions for vestibular schwannoma. Jpn J Clin Oncol 2013; 43 (08) 805-812
    CrossrefPubMedGoogle Scholar
  • 53 Tsai JT, Lin JW, Lin CM. et al. Clinical evaluation of CyberKnife in the treatment of vestibular schwannomas. BioMed Res Int 2013; 2013: 297093 DOI: 10.1155/2013/297093.
    CrossrefPubMedGoogle Scholar
  • 54 Vivas EX, Wegner R, Conley G. et al. Treatment outcomes in patients treated with CyberKnife radiosurgery for vestibular schwannoma. Otol Neurotol 2014; 35 (01) 162-170
    CrossrefPubMedGoogle Scholar
  • 55 Casentini L, Fornezza U, Perini Z, Perissinotto E, Colombo F. Multisession stereotactic radiosurgery for large vestibular schwannomas. J Neurosurg 2015; 122 (04) 818-824
    CrossrefPubMedGoogle Scholar
  • 56 Çakır O, Berkiten G, Tutar B. et al. Effects of CyberKnife therapy for vestibular schwannoma on hearing: a retrospective study. J Laryngol Otol 2018; 132 (09) 796-801
    CrossrefPubMedGoogle Scholar
  • 57 Gallogly JA, Jumaily M, Faraji F, Mikulec AA. Stereotactic radiotherapy in three weekly fractions for the management of vestibular schwannomas. Am J Otolaryngol 2018; 39 (05) 561-566
    CrossrefPubMedGoogle Scholar
  • 58 Przybylowski CJ, Baranoski JF, Paisan GM. et al. CyberKnife radiosurgery for acoustic neuromas: Tumor control and clinical outcomes. J Clin Neurosci 2019; 63: 72-76
    CrossrefPubMedGoogle Scholar
  • 59 Pialat PM, Fieux M, Tringali S, Beldjoudi G, Pommier P, Tanguy R. Vestibular Schwannoma: Results of Hypofractionated Stereotactic Radiation Therapy. Adv Radiat Oncol 2021; 6 (04) 100694 DOI: 10.1016/j.adro.2021.100694.
    CrossrefPubMedGoogle Scholar
  • 60 Puataweepong P, Dhanachai M, Swangsilpa T. et al. Long-term clinical outcomes of stereotactic radiosurgery and hypofractionated stereotactic radiotherapy using the CyberKnife® robotic radiosurgery system for vestibular schwannoma. Asia Pac J Clin Oncol 2021; ••• DOI: 10.1111/ajco.13592.
    CrossrefPubMedGoogle Scholar
  • 61 Koos WT, Day JD, Matula C, Levy DI. Neurotopographic considerations in the microsurgical treatment of small acoustic neurinomas. J Neurosurg 1998; 88 (03) 506-512 DOI: 10.3171/jns.1998.88.3.0506.
    CrossrefPubMedGoogle Scholar
  • 62 Yang I, Sughrue ME, Han SJ. et al. A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannoma. J Neurosurg 2010; 112 (04) 851-859
    CrossrefPubMedGoogle Scholar
  • 63 Fong BM, Pezeshkian P, Nagasawa DT, De Salles A, Gopen Q, Yang I. Hearing preservation after LINAC radiosurgery and LINAC radiotherapy for vestibular schwannoma. J Clin Neurosci 2012; 19 (08) 1065-1070
    CrossrefPubMedGoogle Scholar