Role of Platelets and Their Interaction with Immune Cells in Venous Thromboembolism

Zhao Zhang; Xianghui Zhou; Xin Zhou; Zhipeng Cheng; Yu Hu

doi:10.1055/s-0044-1789022

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2025; 51(08): 870-878
DOI: 10.1055/s-0044-1789022

Review Article

Role of Platelets and Their Interaction with Immune Cells in Venous Thromboembolism

Authors

Zhao Zhang^*

¹Department of Hematology, Huazhong University of Science and Technology, Union Hospital, Tongji Medical College, Wuhan, China
Xianghui Zhou^*

¹Department of Hematology, Huazhong University of Science and Technology, Union Hospital, Tongji Medical College, Wuhan, China
Xin Zhou^*

¹Department of Hematology, Huazhong University of Science and Technology, Union Hospital, Tongji Medical College, Wuhan, China
Zhipeng Cheng

¹Department of Hematology, Huazhong University of Science and Technology, Union Hospital, Tongji Medical College, Wuhan, China
Yu Hu

¹Department of Hematology, Huazhong University of Science and Technology, Union Hospital, Tongji Medical College, Wuhan, China

Abstract

Venous thromboembolism (VTE) represents a significant global health challenge, ranking as the third leading cause of cardiovascular-related mortality. VTE pervades diverse clinical specialties, posing substantial risks to patient well-being and imposing considerable economic strains on health care systems. While platelets have long been recognized as pivotal players in hemostasis, emerging evidence underscores their multifaceted immune functions and their capacity to engage in crosstalk with other immune cells, such as neutrophils, thereby fostering immune-related thrombosis. Notably, investigations have elucidated the pivotal role of platelets in the pathogenesis of VTE. This review provides a comprehensive overview of platelet physiology, encompassing their activation, secretion dynamics, and implications in VTE. Moreover, it delineates the impact of platelet interactions with various immune cells on the initiation and progression of VTE, explores the correlation between platelet-related laboratory markers and VTE, and elucidates the role of platelets in thrombosis regression.

Keywords

platelets - immune cells - venous thromboembolism - hemostasis - immune thrombosis - thrombosis regression

Full Text

References

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