PDF herunterladen
Semin Liver Dis 2024; 44(03): 300-318
DOI: 10.1055/s-0044-1789207
Review Article

Role of Neutrophils in the Development of Steatotic Liver Disease

Autoren

  • You-Jin Choi

    1   College of Pharmacy, Daegu Catholic University, Gyeongsan, Republic of Korea

  • Yeonsoo Kim

    2   College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Republic of Korea

  • Seonghwan Hwang

    2   College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Republic of Korea

Funding This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT; grant no. 2022R1C1C1003563 to S.H. and grant no. 2021R1C1C2004529 to Y-J.C.).
Weitere Informationen
   Lizenzen und Reprints


Graphical Abstract

Abstract

This review explores the biological aspects of neutrophils, their contributions to the development of steatotic liver disease, and their potential as therapeutic targets for the disease. Although alcohol-associated and metabolic dysfunction-associated liver diseases originate from distinct etiological factors, the two diseases frequently share excessive lipid accumulation as a common contributor to their pathogenesis, thereby classifying them as types of steatotic liver disease. Dysregulated lipid deposition in the liver induces hepatic injury, triggering the activation of the innate immunity, partially through neutrophil recruitment. Traditionally recognized for their role in microbial clearance, neutrophils have recently garnered attention for their involvement in sterile inflammation, a pivotal component of steatotic liver disease pathogenesis. In conclusion, technological innovations, including single-cell RNA sequencing, have gradually disclosed the existence of various neutrophil subsets; however, how the distinct subsets of neutrophil population contribute differentially to the development of steatotic liver disease remains unclear.

Keywords

neutrophil - steatosis - alcohol-associated liver disease - metabolic dysfunction-associated liver disease


Publikationsverlauf

Artikel online veröffentlicht:
08. August 2024

© 2024. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA