Enterobacter cloacae as a Rare Cause of Cerebral Abscesses in a Neonatal Late-Onset Sepsis—a Case Report and Literature Review with Focus on Risk Factors, Diagnostics, and Treatment

Yildiz Yildirim; Ruy Perez; Rüdiger Wentzell; Clemens Andrée; Martin Weinzierl; Norbert Utz; Tim Niehues

doi:10.1055/s-0044-1793910

Journal of Pediatric Infectious Diseases, Inhaltsverzeichnis

J Pediatr Infect Dis
DOI: 10.1055/s-0044-1793910

Case Report

Enterobacter cloacae as a Rare Cause of Cerebral Abscesses in a Neonatal Late-Onset Sepsis—a Case Report and Literature Review with Focus on Risk Factors, Diagnostics, and Treatment

Authors

Yildiz Yildirim

¹Department of Pediatrics, Helios Klinikum, Academic Hospital of RWTH Aachen University, Krefeld, Germany
Ruy Perez

¹Department of Pediatrics, Helios Klinikum, Academic Hospital of RWTH Aachen University, Krefeld, Germany
Rüdiger Wentzell

²Department of Pediatrics, Rheinlandklinikum, Neuss, Germany
Clemens Andrée

¹Department of Pediatrics, Helios Klinikum, Academic Hospital of RWTH Aachen University, Krefeld, Germany
Martin Weinzierl

³Department of Neurosurgery and Spinal Surgery, Helios Klinikum, Academic Hospital of RWTH Aachen University, Krefeld, Germany
Norbert Utz

⁴Department of Diagnostic and Interventional Radiology, Helios Klinikum, Academic Hospital of RWTH Aachen University, Krefeld, Germany
Tim Niehues

¹Department of Pediatrics, Helios Klinikum, Academic Hospital of RWTH Aachen University, Krefeld, Germany

Abstract

Late-onset sepsis (LOS; sepsis occurring after the first 72 h of life) increases the morbidity and mortality of premature neonates, especially those with very low birth weight (≤1,500 g). In LOS, Enterobacter cloacae has been rarely described as a cause of secondary brain abscesses. Our case report summarizes important aspects of cerebral abscesses due to an E. cloacae sepsis in a preterm neonate. Our patient received surgical abscess drainage and rational antibiotic treatment, employing prolonged meropenem infusions plus fosfomycin and subsequent treatment with oral trimethoprim/sulfamethoxazole. Furthermore, we present a review of the current literature from 2009 to 2022, comparing cases similar to our case.

Keywords

cerebral abscesses - Enterobacter cloacae - neonatal sepsis - late-onset sepsis - antimicrobial resistance

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Referenzen

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