Vitamin A metabolism in MASLD development during mouse aging

Declines in hepatic lipid metabolism are linked to the development of steatotic liver disease and sarcopenia during aging, though the origins and directionality of these associations remain unexplained. Impairments in Vitamin A (VitA) metabolism are evident in steatotic liver disease, yet their functional roles have not been investigated. This study elucidates that a Vitamin A-free diet (VAFD) influences lipid metabolism in the aging liver. We will present specific mechanisms that contribute to this rescue during specific time-windows of organism aging. In addition, we present data indicating that aging-associated impairments in liver fat metabolism influences sarcopenia development in geriatric mice by induction of specific catabolic pathways. The results support the model that aging does not progress uniformly across all organs, highlighting hepatic lipid metabolism as a critical vulnerability causing comorbidities , which can be mitigated by liver-specific reactivation of lipid metabolism.

Publication History

Article published online:
20 January 2025