Abstract
Introduction Biotissues are defined as organized combinations of synthetic and/or biological substances
that interact with complex biological systems to treat, replace, or remodel tissues
and organs. Tissue bioengineering employs a variety of methods, including the use
of biological and synthetic scaffolds, along with interactions involving stem cells
and cytokines. The present review evaluates the techniques and methods for biotissue
synthesis, as well as their efficacy in both animal and human models.
Materials and Methods A systematic literature review was conducted using the PubMed, Lilacs, Scielo, and
Cochrane databases, employing specific descriptors. The analysis focused on identifying
the countries of origin of the studies and categorizing the techniques and resources
utilized, with the aim of informing the selection of strategies for the application
of biotissues in reconstructive plastic surgery.
Results Among the 37 selected articles, 15 focused on in vitro experimentation, 14 on in
vivo experimentation, and 8 employed both approaches. The studies were further categorized
into 3 primary subtopics: adipogenesis (18 articles), angiogenesis (10 articles),
and chondrogenesis (9 articles), all relevant to tissue reconstruction.
Conclusion Advances in the use of biomaterials in regenerative medicine are promising, with
experimental results aligning well with contemporary plastic surgery practices. While
human application remains limited, the potential of stem cells and growth factors
suggests significant future developments, warranting further focused studies. The
present review elucidates the technologies and progress in the use of biomaterials,
highlighting their impact on the technical evolution of reconstructive plastic surgery.
Keywords biomaterials - reconstructive plastic surgery - scaffolds
Bibliographical Record
