Applications of Biotissues in Plastic Surgery: A Systematic Review

Abstract

Introduction Biotissues are defined as organized combinations of synthetic and/or biological substances that interact with complex biological systems to treat, replace, or remodel tissues and organs. Tissue bioengineering employs a variety of methods, including the use of biological and synthetic scaffolds, along with interactions involving stem cells and cytokines. The present review evaluates the techniques and methods for biotissue synthesis, as well as their efficacy in both animal and human models.

Materials and Methods A systematic literature review was conducted using the PubMed, Lilacs, Scielo, and Cochrane databases, employing specific descriptors. The analysis focused on identifying the countries of origin of the studies and categorizing the techniques and resources utilized, with the aim of informing the selection of strategies for the application of biotissues in reconstructive plastic surgery.

Results Among the 37 selected articles, 15 focused on in vitro experimentation, 14 on in vivo experimentation, and 8 employed both approaches. The studies were further categorized into 3 primary subtopics: adipogenesis (18 articles), angiogenesis (10 articles), and chondrogenesis (9 articles), all relevant to tissue reconstruction.

Conclusion Advances in the use of biomaterials in regenerative medicine are promising, with experimental results aligning well with contemporary plastic surgery practices. While human application remains limited, the potential of stem cells and growth factors suggests significant future developments, warranting further focused studies. The present review elucidates the technologies and progress in the use of biomaterials, highlighting their impact on the technical evolution of reconstructive plastic surgery.

Keywords

biomaterials - reconstructive plastic surgery - scaffolds

Authors' Contributions

RSA: analysis and/or data interpretation, conception and design study, conceptualization, data curation, final manuscript approval, formal analysis, funding acquisition, investigation, methodology, project administration, resources, supervision, validation, visualization, writing—original draft preparation, and Writing—review & editing; MGVBM: analysis and/or data interpretation, conceptualization, data curation, formal analysis, methodology, and writing—original draft preparation; NTS: analysis and/or data interpretation, conception and design study, conceptualization, formal analysis, investigation, project administration, resources, validation, and writing—original draft preparation; EBG: supervision, visualization, and writing—review & editing; LMF: Conception and design study, supervision, validation, visualization, writing—review & editing.

Ethics Committee

CEUA UNIFESP Nr. 1966101023.

Publikationsverlauf

Eingereicht: 09. Oktober 2023

Angenommen: 29. September 2024

Artikel online veröffentlicht:
27. Januar 2025

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