Insights from Ayurveda for Diabetes, Oral Health, and Their Interface

Biju Thomas; Supriya Bhalerao; Maya Indurkar; Manas V. Vyas; Sameer Mahajan; P. L. Ravishankar; Ashish Jain; Ashish Kumar; Vishakha Grover

doi:10.1055/s-0044-1801764

Journal of Health and Allied Sciences NU, Table of Contents

CC BY 4.0 · Journal of Health and Allied Sciences NU
DOI: 10.1055/s-0044-1801764

Review Article

Insights from Ayurveda for Diabetes, Oral Health, and Their Interface

Authors

Biju Thomas

¹Department of Periodontics, AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka, India
Supriya Bhalerao

²Obesity-Diabetes Laboratory, Interactive Research School for Health Affairs, Pune, Maharashtra, India
Maya Indurkar

³Department of Periodontology, Government Dental College and Hospital, Aurangabad, Maharashtra, India
Manas V. Vyas

⁴Head Regulatory Affairs, Colgate-Palmolive (India) Ltd., Mumbai, Maharashtra, India
Sameer Mahajan

⁵MD Ayurveda Medicine, Uranus Health Home and Research Center, Mulund, East Mumbai
P. L. Ravishankar

⁶Department of Periodontics, SRM Kattankulathur Dental College, Potheri, Tamil Nadu, India
Ashish Jain

⁷Department of Periodontology, Dr. H. S. J. Institute of Dental Sciences, Punjab University, Chandigarh, India
Ashish Kumar

⁸Department of Periodontology, Dental College, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India
Vishakha Grover

⁷Department of Periodontology, Dr. H. S. J. Institute of Dental Sciences, Punjab University, Chandigarh, India

Abstract

Diabetes-related metabolic disturbances have a negative impact on oral health as well. The reciprocal relationship between periodontal health and glycemic management has been already established. Both these pose important concerns to public health, and need to be addressed carefully. Ayurveda, the Indian Traditional Medicine System, has dealt in detail with the pathophysiology and management of prameha (diabetes) as well as various oral diseases including dantamoola vyadhi (periodontal diseases). Interestingly, the causative factors for dantamoola vyadhi are greatly similar to those of prameha. Ayurveda propounds formulations such as triphala, which are reported to possess antihyperglycemic activity as well as antimicrobial activity. Hence, such formulations can prove helpful in the management of both these diseases. Considering the global upsurge in research on traditional medicines worldwide, it is the need of the hour to consider the role of Ayurveda in the oral health issues of diabetic patients. The present review discusses the Ayurvedic concepts of diabetes and periodontal health along with their management.

Keywords

prameha - oral health - dantamoola vyadhi - pyorrhea

Full Text

References

References
1 Genco RJ, Graziani F, Hasturk H. Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus. Periodontol 2000 2020; 83 (01) 59-65
2 Charak Samhita, Nidana Sthana, Prameha Nidan, Chapter 4. Accessed at: https://niimh.nic.in/ebooks/ecaraka/?mod=read
3 Chandran S, Mangalasseri P, Patgiri BJ. et al. Diabetis mellitus in Ayurveda WSR to its aetiopathogenesis. Int J Curr Res 2017; 9: 49173-49177
4 Charak Samhita. Chapter 6, Accessed at https://niimh.nic.in/ebooks/ecaraka/?mod=read
5 Mittra S, Bansal VS, Bhatnagar PK. From a glucocentric to a lipocentric approach towards metabolic syndrome. Drug Discov Today 2008; 13 (5–6): 211-218
6 Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 2018; 14 (02) 88-98
7 Hardy ML, Coulter I, Venuturupalli S. et al. Ayurvedic interventions for diabetes mellitus: a systematic review. Evid Rep Technol Assess (Summ) 2001; 41 (41) 2p
8 Unnikrishnan AG, Bhattacharyya A, Baruah MP, Sinha B, Dharmalingam M, Rao PV. Importance of achieving the composite endpoints in diabetes. Indian J Endocrinol Metab 2013; 17 (05) 835-843
9 Einarson TR, Garg M, Kaur V, Hemels ME. Composite endpoints in trials of type-2 diabetes. Diabetes Obes Metab 2014; 16 (06) 492-499
10 Sharma R, Amin H, Ruknuddin G, Prajapati PK. Efficacy of ayurvedic remedies in type 2 diabetes: a review through works done at Gujarat Ayurved University, Jamnagar. J Med Nutr Nutraceut 2015; 4: 63-69
11 Khandelwal N, Dhundi SN, Yadav P, Prajapati PK. Prevention and management of diabetes mellitus in Ayurveda. Asian J Biomed Pharmaceut Sci 2011; 1: 1-6
12 Srikanth N, Haripriya N, Singh R, , Manjula, Tewari D. Diabetes mellitus (Madhumeha) and ayurvedic management: an evidence based approach. World J Pharm Pharm Sci 2015; 4: 881-892
13 Charak Samhita, Chikitsa Sthana, Trishna Chikitsa. Chapter 22. Accessed at https://niimh.nic.in/ebooks/ecaraka/?mod=read
14 Sen G. Siddhantanidanam: A Textbook of Etiology, Pathology, Symptomatology (Part I and II). Translated by Srikanthamurthy KR. Varanasi: Chaukhamba Sanskrit Series Office; 1924
15 Gond P, Singh L. Concept of infected wound (DushtaVrana) in ayurveda. J Adv Res Ayur Yoga Unani Sidd Homeo 2017; 4: 11-15
16 Egede LE, Ye X, Zheng D, Silverstein MD. The prevalence and pattern of complementary and alternative medicine use in individuals with diabetes. Diabetes Care 2002; 25 (02) 324-329
17 Gordon A, Buch Z, Baute V, Coeytaux R. Use of ayurveda in the treatment of type 2 diabetes mellitus. Glob Adv Health Med 2019; 8: 2164956119861094
18 Chauhan A, Semwal RB, Semwal DK. Ayurvedic approaches used in prevention and treatment of type 2 diabetes mellitus. J Convent Knowl Holist Health 2017; 1: 1-15
19 Khan F, Sarker MMR, Ming LC. et al. Comprehensive review on phytochemicals, pharmacological and clinical potentials of Gymnema sylvestre . Front Pharmacol 2019; 10: 1223
20 Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: a systematic review. J Tradit Complement Med 2014; 5 (01) 21-26
21 Peter EL, Kasali FM, Deyno S. et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: systematic review and meta-analysis. J Ethnopharmacol 2019; 231: 311-324
22 Ahmad A, Husain A, Mujeeb M. et al. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac J Trop Biomed 2013; 3 (05) 337-352
23 Liang Y, Xu X, Yin M. et al. Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis. Endocr J 2019; 66 (01) 51-63
24 Gupta BP, Sharma I, Kohli N, Sharma S, Rathi A, Sharma AK. Preliminary clinical assessment and non- toxicity evaluation of an ayurvedic formulation BGR-34 in NIDDM. J Tradit Complement Med 2018; 8 (04) 506-514
25 Setia M, Meena K, Madaan A, Srikanth N, Dhiman KS, Sastry JLN. In vitro studies on antidiabetic potential of new dosage forms of AYUSH 82. J Drug Res Ayurvedic Sci 2017; 2: 1-9
26 Panda AK, Ratha KK, Rao MM. Efficacy of ayurveda formulation Ayush-82 (IME-9) in newly diagnosed type 2 diabetics: retrospective analysis of individual data. J Tradit Med Clin Naturop 2017; 6: 250
27 Pandey RK, Bhatt NN, Singhala TM, Shukla VD. A comparative study of Vamana and Virechana Karma in the management of Sthula Pramehi w.s.r. to Type-2 diabetes. Ayu 2011; 32 (04) 536-539
28 Chen TS, Liou SY, Wu HC. et al. Efficacy of epigallocatechin-3-gallate and Amla (Emblica officinalis) extract for the treatment of diabetic-uremic patients. J Med Food 2011; 14 (7–8): 718-723
29 Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and type 2 diabetes mellitus: prevention and treatment. Nutrients 2019; 11 (08) 1837
30 Vora A, Varghese A, Kachwala Y. et al. Eugenia jambolana extract reduces the systemic exposure of Sitagliptin and improves conditions associated with diabetes: a pharmacokinetic and a pharmacodynamic herb-drug interaction study. J Tradit Complement Med 2018; 9 (04) 364-371
31 Geberemeskel GA, Debebe YG, Nguse NA. Antidiabetic effect of Fenugreek seed powder solution (Trigonella foenum- graecum L.) on hyperlipidemia in diabetic patients. J Diabetes Res 2019; 2019: 8507453
32 Najdi RA, Hagras MM, Kamel FO, Magadmi RM. A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes. Afr Health Sci 2019; 19 (01) 1594-1601
33 Waheed A, Miana GA, Ahmad SI. Clinical investigation of hypoglycemic effect of seeds of Azadirachta-inidca in type-2 (NIDDM) diabetes mellitus. Pak J Pharm Sci 2006; 19 (04) 322-325
34 Nakanekar A, Kohli K, Tatke P. Ayurvedic polyherbal combination (PDBT) for prediabetes: a randomized double blind placebo controlled study. J Ayurveda Integr Med 2019; 10 (04) 284-289
35 Amruthesh S. Dentistry and Ayurveda - IV: classification and management of common oral diseases. Indian J Dent Res 2008; 19 (01) 52-61
36 Ashtanga Hridaya Uttarasthana. Chapter 21, Mukharoga vigyaniya, Verse 1–2. Accessed December 22, 2024 at: https://vedotpatti.in/samhita/Vag/ehrudayam/?mod=read
37 Ayurvedic Medicine: In Depth, National Center for Complementary and Integrative Health. https://www.nccih.nih.gov/health/ayurvedic-medicine-in-depth
38 Singh A, Purohit B. Tooth brushing, oil pulling and tissue regeneration: A review of holistic approaches to oral health. J Ayurveda Integr Med 2011; 2 (02) 64-68
39 Al lafi T, Ababneh H. The effect of the extract of the miswak (chewing sticks) used in Jordan and the Middle East on oral bacteria. Int Dent J 1995; 45 (03) 218-222
40 Maurya DK, Mittal N, Sharma KR, Nath G. Role of triphala in the management of peridontal disease. Anc Sci Life 1997; 17 (02) 120-127
41 Akhtar MS, Ajmal M. Significance of chewing-sticks (miswaks) in oral hygiene from a pharmacological view-point. J Pak Med Assoc 1981; 31 (04) 89-95
42 Sharma H, Chandola HM. Prameha in Ayurveda: correlation with obesity, metabolic syndrome, and diabetes mellitus. Part 1-etiology, classification, and pathogenesis. J Altern Complement Med 2011; 17 (06) 491-496