Obesity related IL-6 trans-signaling is linked to BMI in pediatric asthma and associated with premature aging of respiratory epithelial cells in mice and children

¹ University of Cologne, University Hospital Cologne, Department of Pediatrics and Adolescent Medicine, Department of Pediatric Pulmonology and Allergology, Köln, North Rhine-Westphalia, Germany

² University of Cologne, University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), Köln, North Rhine-Westphalia, Germany

⁶ Hannover Medical School, Department of pediatric Pneumology, Allergology and Neonatology, Hannover, Lower Saxony, Germany

⁷ Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Lower Saxony, Germany

³ Airway Research Center North (ARCN), Germany

⁸ Division of Pediatric Pneumology and Allergology, University Children's Hospital Lübeck, University Medical Center Schleswig-Holstein, Lübeck, Schleswig-Holstein, Germany

³ Airway Research Center North (ARCN), Germany

⁸ Division of Pediatric Pneumology and Allergology, University Children's Hospital Lübeck, University Medical Center Schleswig-Holstein, Lübeck, Schleswig-Holstein, Germany

¹² Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany

¹ University of Cologne, University Hospital Cologne, Department of Pediatrics and Adolescent Medicine, Department of Pediatric Pulmonology and Allergology, Köln, North Rhine-Westphalia, Germany

¹ University of Cologne, University Hospital Cologne, Department of Pediatrics and Adolescent Medicine, Department of Pediatric Pulmonology and Allergology, Köln, North Rhine-Westphalia, Germany

² University of Cologne, University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), Köln, North Rhine-Westphalia, Germany

⁴ University of Bern, Inselspital, Department of Pediatrics, Bern, Bern, Switzerland

⁵ LungenClinic Grosshansdorf GmbH, Grosshansdorf, Schleswig-Holstein, Germany

⁶ Hannover Medical School, Department of pediatric Pneumology, Allergology and Neonatology, Hannover, Lower Saxony, Germany

⁷ Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Lower Saxony, Germany

⁶ Hannover Medical School, Department of pediatric Pneumology, Allergology and Neonatology, Hannover, Lower Saxony, Germany

⁷ Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Lower Saxony, Germany

³ Airway Research Center North (ARCN), Germany

⁸ Division of Pediatric Pneumology and Allergology, University Children's Hospital Lübeck, University Medical Center Schleswig-Holstein, Lübeck, Schleswig-Holstein, Germany

⁶ Hannover Medical School, Department of pediatric Pneumology, Allergology and Neonatology, Hannover, Lower Saxony, Germany

⁷ Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Lower Saxony, Germany

⁹ Ludwig Maximilians University, Dr. von Hauner Children's Hospital, München, Bavaria, Germany

¹⁰ Comprehensive Pneumology Center Munich, Member of the German Center for Lung Research (DZL), München, Bavaria, Germany

¹¹ German Center for Child and Adolescent Health (DZKJ), Dr von Hauner Children's Hospital, LMU Munich, Germany

⁹ Ludwig Maximilians University, Dr. von Hauner Children's Hospital, München, Bavaria, Germany

¹⁰ Comprehensive Pneumology Center Munich, Member of the German Center for Lung Research (DZL), München, Bavaria, Germany

¹ University of Cologne, University Hospital Cologne, Department of Pediatrics and Adolescent Medicine, Department of Pediatric Pulmonology and Allergology, Köln, North Rhine-Westphalia, Germany

¹ University of Cologne, University Hospital Cologne, Department of Pediatrics and Adolescent Medicine, Department of Pediatric Pulmonology and Allergology, Köln, North Rhine-Westphalia, Germany

³ Airway Research Center North (ARCN), Germany

⁸ Division of Pediatric Pneumology and Allergology, University Children's Hospital Lübeck, University Medical Center Schleswig-Holstein, Lübeck, Schleswig-Holstein, Germany

¹² Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany

⁶ Hannover Medical School, Department of pediatric Pneumology, Allergology and Neonatology, Hannover, Lower Saxony, Germany

⁷ Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Lower Saxony, Germany

¹ University of Cologne, University Hospital Cologne, Department of Pediatrics and Adolescent Medicine, Department of Pediatric Pulmonology and Allergology, Köln, North Rhine-Westphalia, Germany

² University of Cologne, University Hospital Cologne, Translational Experimental Pediatrics, Department of Pediatric and Adolescent Medicine, Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), Köln, North Rhine-Westphalia, Germany

¹³ Institute for Lung Health (ILH) and Cardiopulmonary Institute (CPI), University of Giessen and Marburg Lung Centre (UGMLC), Member of the German Centre for Lung Research (DZL), Giessen, Hesse, Germany