Abstract
Background
Levodopa-induced dyskinesia (LID) remains a significant motor complication in Parkinson's
disease (PD), although opinions differ on its clinical relevance.
Objective
To explore the current prevalence and impact of LID, we analyzed two cohorts from
the Latin American Research Consortium on the Genetics of Parkinson's Disease from
movement disorder clinics in the city of São Paulo, Brazil, recruited 10 years apart.
Methods
The cohorts included 187 individuals diagnosed with PD in phase 1 (2007–2014) and
224 in phase 2 (2021–2022). The presence and functional impact of LID were measured
using part IV (items 4.1 and 4.2 respectively) of the Movement Disorder Society Unified
Parkinson's Disease Rating Scale (MDS-UPDRS).
Results
The analysis revealed that LID frequency increased from 34.7 in phase 1 to 54.9% in
phase 2 (more recent), with functional impact rising from 25.1 to 38.8%.
Conclusion
The findings suggest that LID remains a relevant clinical issue in clinics specialized
in movement disorders in Brazil, with no reduction in prevalence throughout the last
decade. Further studies from other regions and less specialized neurology centers
may help understand this motor complication in Brazil and in other developing countries.
Keywords Parkinson Disease - Dyskinesias - Levodopa - Brazil
Bibliographical Record
