Abstract
Objective
Hydrogel-based, gypsum, calcium carbonate (CaCO3 ) bone scaffolding materials and antibacterial extracts from cinnamaldehyde herbal
ingredients are a combination of smart materials that are abundant and environmental
friendly. That component is a promising candidate for bone scaffold material. This
prototype has been designed as an injectable paste that is easy to apply, fills in
bone and dental defects, and quickly polymerizes with the help of ultraviolet (UV)
light. The purpose of this study is to investigate the effects of adding cinnamaldehyde
to injectable gypsum–CaCO3 hydrogel paste that has undergone UV light polymerization for biodegradable implant
material.
Materials and Methods
A composite material was synthesized named Cia by a combination of gelatin, gypsum,
CaCO3 , and cinnamaldehyde compound assisted by UV light polymerization. An in vitro and in vivo quasi-experiments were conducted in this study, including material characterization
and testing. Material characterization was performed using Fourier transform infrared
spectroscopy) and scanning electron microscope. Material testing examined the swelling
ratio and degradation rate. Antibacterial activity was performed as in vitro testing undergone Streptococcus sanguinis and Pseudomonas aeruginosa . Data were analyzed statistically using an independent t -test (p < 0.05). A total of 21 male Wistar rats were used in vivo study. A femoral condyle was chosen as a hard tissue representative of the jaw. Tissues
were then stained with hematoxylin–eosin and Mallory staining observed under a light
microscope to identify the tissue regeneration and implant remaining.
Conclusion
Synthesized material that is added by cinnamaldehyde could be an implant material
for inducing tissue regeneration.
Keywords cinnamaldehyde - injectable paste - ultraviolet - polymerization - scaffold - implant
