Abstract
This review aims to address the framework for classification of anal dysplasia, immunogenic
and behavioral risk factors for development of disease, the progression to anal cancer,
and key intervention points to guide contemporary practice. Although anal cancer is
rare, its rising incidence and disproportionate impact on racial minorities, immunocompromised
individuals, and older adults require attention to combat high disease burden within
these communities. Concentrated efforts with targeted resource allocation are required
to address this rising disease incidence, following new screening guidelines developed
to identify groups that are considered high-risk for anal dysplasia and the development
of anal squamous cell carcinoma.
Keywords
anal dysplasia - anal cancer - anal squamous cell carcinoma - human papillomavirus
