Abstract
Herpes reactivation following posterior fossa surgery is an underrecognized but clinically
significant complication. This case series describes three patients who developed
herpes labialis within 3 to 4 days after posterior fossa surgery involving the trigeminal
nerve. Surgical stress, direct nerve manipulation, and perioperative corticosteroid
use likely contributed to reactivation. Prompt diagnosis and early antiviral therapy
with acyclovir led to complete resolution in all cases. These findings highlight the
need for greater awareness, early recognition, and potential prophylactic antiviral
use in high-risk neurosurgical procedures to prevent herpes-related complications.
Keywords
herpes virus - herpes reactivation - posterior fossa surgery - herpes labialis - acyclovir