Single cell characterization of resistance mechanisms to EGFR-targeted therapy in colorectal cancer patient derived organoids

Z Li; J G Gleixner; R Riedke; H Susak; E Valentini; T Mulholland; P Albrecht; J Yu; L Tondo; E Karabati; K Trikhirhisthit; P Sui; Y Petersen; T Miersch; K Nowicki-Osuch; O Stegle; M P Ebert; M Boutros; J Betge

doi:10.1055/s-0045-1810912

Zeitschrift für Gastroenterologie, Table of Contents

Z Gastroenterol 2025; 63(08): e520-e521
DOI: 10.1055/s-0045-1810912

Abstracts | DGVS/DGAV

Kurzvorträge

Molekulare Therapie des kolorektalen Karzinoms Donnerstag, 18. September 2025, 10:50 – 12:07, Vortragsraum 11

Single cell characterization of resistance mechanisms to EGFR-targeted therapy in colorectal cancer patient derived organoids

Z Li

¹Heidelberg University, Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Deutschland

²German Cancer Research Center (DKFZ), Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, Heidelberg, Deutschland

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J G Gleixner

³German Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics, Heidelberg, Deutschland

,

R Riedke

¹Heidelberg University, Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Deutschland

²German Cancer Research Center (DKFZ), Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, Heidelberg, Deutschland

³German Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics, Heidelberg, Deutschland

,

H Susak

⁴German Cancer Research Center (DKFZ), Computational Genomics and Systems Genetics, Heidelberg, Deutschland

,

E Valentini

³German Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics, Heidelberg, Deutschland

,

T Mulholland

¹Heidelberg University, Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Deutschland

²German Cancer Research Center (DKFZ), Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, Heidelberg, Deutschland

,

P Albrecht

¹Heidelberg University, Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Deutschland

²German Cancer Research Center (DKFZ), Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, Heidelberg, Deutschland

,

J Yu

⁵The First Affiliated Hospital of Sun Yat-sen University, Department of Andrology, Guangzhou, China

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L Tondo

¹Heidelberg University, Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Deutschland

²German Cancer Research Center (DKFZ), Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, Heidelberg, Deutschland

,

E Karabati

¹Heidelberg University, Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Deutschland

²German Cancer Research Center (DKFZ), Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, Heidelberg, Deutschland

,

K Trikhirhisthit

¹Heidelberg University, Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Deutschland

²German Cancer Research Center (DKFZ), Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, Heidelberg, Deutschland

,

P Sui

¹Heidelberg University, Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Deutschland

²German Cancer Research Center (DKFZ), Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, Heidelberg, Deutschland

,

Y Petersen

¹Heidelberg University, Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Deutschland

²German Cancer Research Center (DKFZ), Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, Heidelberg, Deutschland

,

T Miersch

³German Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics, Heidelberg, Deutschland

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K Nowicki-Osuch

⁶German Cancer Research Center (DKFZ), Junior Research Group Tumorigenesis and Molecular Cancer Prevention, Heidelberg, Deutschland

⁷DKFZ Hector Cancer Institute, University Medical Center Mannheim, Mannheim, Deutschland

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O Stegle

⁴German Cancer Research Center (DKFZ), Computational Genomics and Systems Genetics, Heidelberg, Deutschland

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M P Ebert

¹Heidelberg University, Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Deutschland

⁷DKFZ Hector Cancer Institute, University Medical Center Mannheim, Mannheim, Deutschland

,

M Boutros

³German Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics, Heidelberg, Deutschland

,

J Betge

¹Heidelberg University, Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Deutschland

²German Cancer Research Center (DKFZ), Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, Heidelberg, Deutschland

⁷DKFZ Hector Cancer Institute, University Medical Center Mannheim, Mannheim, Deutschland

› Author Affiliations