Diffuse midline gliomas (DMGs), H3K27-altered, are rare and aggressive tumors primarily
affecting children, though adult cases occur. These gliomas present significant surgical
challenges, and novel techniques are needed to improve outcomes. We present the case
of a 53-year-old male with a solid expansive lesion located at T12 to L1, who presented
with bilateral thigh pain, loss of sphincter control, and increased urinary frequency.
Initial magnetic resonance imaging suggested an ependymoma; however, tumor resection
followed by immunohistochemical analysis confirmed a diagnosis of diffuse midline
glioma, H3K27-altered. The patient underwent a successful two-level lumbar laminectomy
with a microsurgical gross total resection. An innovative technique of intraoperative
infrared thermography mapping was employed, representing a novel approach for this
rare tumor. The patient remains alive at the time of the present publication.
Keywords
glioma - thermography - surgical oncology - spinal cord neoplasms
Bibliographical Record
Gabriel Filipe Soares Quiuqui, Bárbara Moreira Diniz, Antonio Augusto de Carvalho
Duarte, Caio Cesar Martins Pedrosa de Castro, Daniel Mendes de Souza, Artiel Aurino
Sousa Sampaio, Lucas Scharf Oliveira, Lucas Rodrigues de Souza, Marcelo Mamede de
Freitas, Leonardo Augusto Wendling Henriques. Infrared Thermography – A Novel Tool
in the Surgical Treatment of H3 K27M-Altered Diffuse Midline Spinal Cord Glioma: Technical
and Case Report. Brazilian Journal of Oncology 2025; 21: s00451811529.
DOI: 10.1055/s-0045-1811529
