Serum Vitamin D Levels in Autoimmune and Non-Autoimmune Hypothyroidism: A Retrospective Study from Jordan

Hadeel Alqurieny; Mohammad Al-Slehat; Karam Bdour; Roa'a Abedel Razaq Abu Lail; Abdel Qader Abu-Salih; Zaid Iyad Mohammad Aldebei; Mohammad Al-Bdour; Rula Al Shimi; Asmaa Quraan; Abdel Razaq Al Yasin; Fadi Ayyash

doi:10.1055/s-0045-1811590

Avicenna Journal of Medicine, Inhaltsverzeichnis

CC BY 4.0 · Avicenna J Med 2025; 15(03): 116-122
DOI: 10.1055/s-0045-1811590

Original Article

Serum Vitamin D Levels in Autoimmune and Non-Autoimmune Hypothyroidism: A Retrospective Study from Jordan

Authors

Hadeel Alqurieny

¹Department of Endocrinology, Queen Rania Al Abdullah Hospital for Children, Royal Jordanian Medical Services, Amman, Jordan
Mohammad Al-Slehat

²Departmant of Internal Medicine, Jordan University Hospital, Amman, Jordan
Karam Bdour

³Department of Endocrinology, King Hussein Medical Center, Amman, Jordan
Roa'a Abedel Razaq Abu Lail

⁴Faculty of Medicine, Al-Balqa Applied University, Al-Salt, Jordan
Abdel Qader Abu-Salih

⁵Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
Zaid Iyad Mohammad Aldebei

⁴Faculty of Medicine, Al-Balqa Applied University, Al-Salt, Jordan
Mohammad Al-Bdour

⁵Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
Rula Al Shimi

⁵Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
Asmaa Quraan

¹Department of Endocrinology, Queen Rania Al Abdullah Hospital for Children, Royal Jordanian Medical Services, Amman, Jordan
Abdel Razaq Al Yasin

¹Department of Endocrinology, Queen Rania Al Abdullah Hospital for Children, Royal Jordanian Medical Services, Amman, Jordan
Fadi Ayyash

¹Department of Endocrinology, Queen Rania Al Abdullah Hospital for Children, Royal Jordanian Medical Services, Amman, Jordan

Abstract

Background

Vitamin D is a steroid hormone primarily produced in the skin. In Jordan, vitamin D deficiency is widespread among the population. This study aims to compare serum vitamin D levels between patients with autoimmune and non-autoimmune hypothyroidism.

Methods

A retrospective observational study was conducted at the Jordanian Royal Medical Services in Jordan from January 2023 to November 2024. Data were gathered from the patient's medical records, including age, gender, vitamin D level, thyroid-stimulating hormone (TSH) value, free thyroxine (FT4) level, anti-thyroid peroxidase, and anti-thyroglobulin levels.

Results

A total of 150 patients were included, aged 5 to 76 years, with a mean age of 39.2 years. The mean vitamin D level was 17.9 ng/mL, indicating widespread deficiency. There was no significant difference in vitamin D levels between patients with autoimmune and non-autoimmune hypothyroidism (p = 0.860), suggesting that vitamin D levels are independent of autoimmune hypothyroidism status. Additionally, there was no significant relationship between vitamin D levels and TSH (ρ = −0.119, p = 0.148) or FT4 (ρ = 0.128, p = 0.123). Age showed a modest negative correlation with TSH levels (ρ = −0.067, p = 0.416) and a positive but nonsignificant correlation with FT4 levels (ρ = 0.024, p = 0.775).

Conclusion

Serum vitamin D levels do not significantly differ between patients with autoimmune and non-autoimmune hypothyroidism, nor do they correlate with TSH levels. Further studies are needed to evaluate vitamin D status in these patient groups.

Keywords

autoimmune hypothyroidism - non-autoimmune hypothyroidism - 25-hydroxyvitaminD - FT4

Volltext

Referenzen

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