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CC BY 4.0 · Arq Neuropsiquiatr 2025; 83(10): s00451812324
DOI: 10.1055/s-0045-1812324
Review Article

The cerebellar involvement in essential tremor: the connecting roads

Authors

  • Carlos Henrique Ferreira Camargo 

    1   Universidade Federal do Paraná, Programa de Pós-Graduação em Medicina Interna, Disciplina de Doenças Neurodegenerativas, Curitiba PR, Brazil.

  • Léo Coutinho 

    1   Universidade Federal do Paraná, Programa de Pós-Graduação em Medicina Interna, Disciplina de Doenças Neurodegenerativas, Curitiba PR, Brazil.

  • Luís Eduardo B.M. Zubko 

    2   Universidade Federal do Paraná, Departamento de Clínica Médica, Serviço de Neurologia, Curitiba PR, Brazil.

  • Gustavo L. Franklin 

    3   Universidade Federal do Paraná, Departamento de Clínica Médica, Serviço de Clínica Médica, Curitiba PR, Brazil.
    4   Pontifícia Universidade Católica do Paraná, Faculdade de Medicina, Departamento de Clínica Médica, Curitiba PR, Brazil.

  • Hélio Afonso Ghizoni Teive 

    1   Universidade Federal do Paraná, Programa de Pós-Graduação em Medicina Interna, Disciplina de Doenças Neurodegenerativas, Curitiba PR, Brazil.
    2   Universidade Federal do Paraná, Departamento de Clínica Médica, Serviço de Neurologia, Curitiba PR, Brazil.
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Abstract

Essential tremor (ET) is the most prevalent movement disorder globally, affecting about 1% of the general population and 5% of those aged over 65 years. Characterized by involuntary, rhythmic oscillations, it primarily manifests as postural and kinetic tremors, predominantly in the upper limbs. Genetic studies, neuropathological examinations, neurophysiological assessments, and various neuroimaging techniques have demonstrated functional, neurotransmitter-related, and structural abnormalities within the cerebello-thalamo-cortical circuit. These findings collectively portray ET as a neurodegenerative syndrome with diverse etiologies and clinical manifestations, highlighting the involvement of the cerebellum.

Keywords

Essential Tremor - Cerebellum - Purkinje Cells - Inferior Olivary Complex - Cholinergic Antagonists

Authors' Contributions

Conceptualization: HAGT; Methodology: CHFC; Project administration: CHFC, HAGT; Supervision: CHFC, GLF, HAGT; Validation: CHFC, LC, LEBMZ, GLF, HAGT; Visualization: CHFC, LC, LEBMZ, GLF, HAGT; Writing – original draft: CHFC, LC, LEBMZ, GLF; Writing – review & editing: CHFC, HAGT.


Data Availability Statement

The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request.


Editor-in-Chief: Ayrton Roberto Massaro (0000-0002-0487-5299).


Associate Editor: Orlando G. P. Barsottini (0000-0002-0107-0831).




Publication History

Received: 09 April 2025

Accepted: 27 July 2025

Article published online:
27 October 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Carlos Henrique Ferreira Camargo, Léo Coutinho, Luís Eduardo B.M. Zubko, Gustavo L. Franklin, Hélio Afonso Ghizoni Teive. The cerebellar involvement in essential tremor: the connecting roads. Arq Neuropsiquiatr 2025; 83: s00451812324.
DOI: 10.1055/s-0045-1812324