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Synthesis 1986; 1986(7): 564-565
DOI: 10.1055/s-1986-31705
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General Method for Synthesis of Bipyridines: Palladium Catalyzed Cross-coupling Reaction of Trimethylstannyl-pyridines with Bromopyridines

Yutaka Yamamoto* , Yutaka Azuma, Hiroyuki Mitoh
  • *Tohoku College of Pharmacy, 4-4-1 Komatsushima, Sendai 983, Japan
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Publication Date:
20 August 2002 (online)

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Trimethylstannylpyridines 1 were treated with bromopyridines 2 in the presence of catalytic amount of tetrakis(triphenylphosphine)palladium to give the corresponding bipyridines 3 in moderate to good yields. Nicotelline (6) was similarly synthesized from 2, 4-bis(trimethylstannyl)pyridine (5) and 3-bromo-pyridine (2b).

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