Synthesis 1990; 1990(6): 474-475
DOI: 10.1055/s-1990-26908
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Iminophosphorane-Mediated Synthesis of Pyrido[2,3-d]pyrimidine Derivatives

Pedro Molina* , Maria Jesús Vilaplana
  • *Departamento de Química Orgánica, Facultad de Ciencias Quimicas y Matemáticas, Universidad de Murcia, Campus de Espinardo, E-30071, Murcia, Spain
Further Information

Publication History

Publication Date:
17 September 2002 (online)

The 5-(2-nitroethenyl)-6-[(triphenylphosphoranylidene)amino]-pyrimidine derivative 3, prepared from 1,3-dimethyl-2,4-dioxo-6-[(triphenylphosphoranylidene)amino] -1,2,3,4-tetrahydropyrimidine (1) and 1-dimethylamino-2-nitroethylene (2), reacts with aryl isocyanates 4 to give 7-arylamino-1, 3-dimethyl-2,4-dioxo-6-nitro-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidines 6 in good yield.