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Synthesis 1990; 1990(6): 520-522
DOI: 10.1055/s-1990-26926
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A Facile Synthesis of 1-Monosubstituted and Unsymmetrically 1,3-Disubstituted Uracils

Harjit Singh* , Pawan Aggarwal, Subodh Kumar
  • *Department of Chemistry, Guru Nanak Dev University, Amritsar - 143005, India
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Publication Date:
17 September 2002 (online)

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Heating of 2,4-bis(trimethylsiloxy)pyrimidine with functionalised alkyl halides in 1,2-dichloroethane in the presence of iodine affords exclusively 1-substituted uracils, which can be benzylated at N-3 with benzyl chloride under phase-transfer catalysis.

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