Synthesis 1990; 1990(7): 573-574
DOI: 10.1055/s-1990-26944
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An Efficient Synthesis of (1S,2S)-1-Acetoxyl-1-aryl-3-halo-2-phthalimidopropanes

Armin Boerner* , Gudrun Voß
  • *Central Institute of Organic Chemistry, Department of Complex Catalysis, Academy of Sciences of the GDR, Buchbinderstr. 5/6, DDR-2500 Rostock, German Democratic Republic
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Publication History

Publication Date:
17 September 2002 (online)

A convenient synthesis of 3-halo derivatives of chiral 2-amino-1-aryl-1,3-propanediols in good overall yield has been developed using a regioselective esterification with p-toluenesulfonyl chloride and successive replacement of the p-toluenesulfonate group by iodide or bromide in acetic anhydride.