Synthesis 1990; 1990(7): 587-589
DOI: 10.1055/s-1990-26949
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A New Route to 2,5-Diamino-4,6-dichloropyrimidine, A Key Precursor of 9-Substituted Guanines

Michel Legraverend* , Hassane Boumchita, Emile Bisagni
  • *URA 1387 CNRS. Institut Curie, section de Biologie, Bât. 110-112, Centre Universitaire, F-91405 Orsay, France
Further Information

Publication History

Publication Date:
17 September 2002 (online)

An improved synthesis of 2,5-diamino-4,6-dihydroxypyrimidine (7) is reported. The direct chlorination of 7 provides the shortest (2 step) synthesis of 2,5-diamino-4,6-dichloropyrimidine (5) reported to date. The procedure described here affords an easy approach to 5, a key intermediate to various 9-substituted guanines.