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Synthesis 1990; 1990(7): 587-589
DOI: 10.1055/s-1990-26949
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A New Route to 2,5-Diamino-4,6-dichloropyrimidine, A Key Precursor of 9-Substituted Guanines

Michel Legraverend* , Hassane Boumchita, Emile Bisagni
  • *URA 1387 CNRS. Institut Curie, section de Biologie, Bât. 110-112, Centre Universitaire, F-91405 Orsay, France
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Publikationsdatum:
17. September 2002 (online)

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An improved synthesis of 2,5-diamino-4,6-dihydroxypyrimidine (7) is reported. The direct chlorination of 7 provides the shortest (2 step) synthesis of 2,5-diamino-4,6-dichloropyrimidine (5) reported to date. The procedure described here affords an easy approach to 5, a key intermediate to various 9-substituted guanines.

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