Synthesis 1990; 1990(7): 595-596
DOI: 10.1055/s-1990-26953
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A Convenient Synthesis of 3-Chloro-2-alkanones

Norbert De Kimpe* , Pascal Brunet
  • *Laboratory of Organic Chemistry, Faculty of Agricultural Sciences, State University of Gent, Coupure Links 653, B-9000 Gent, Belgium
Further Information

Publication History

Publication Date:
17 September 2002 (online)

3-Chloro-2-alkanones were regiospecifically synthesized from methyl 2-alkyl-3-oxobutanoates by chlorination to afford methyl 2-alkyl-2-chloro-3-oxobutanoates followed by demethoxycarbonylation in acid medium.