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Synthesis 1990; 1990(9): 781-782
DOI: 10.1055/s-1990-27013
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A Facile Synthesis of Methyl 1,5-Disubstituted Imidazole-4-carboxylates

Kiwamu Hiramatsu* , Ken-ichi Nunami, Kimiaki Hayashi, Kazuo Matsumoto
  • *Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd., 16-89 Kashima-3-chome, Yodogawa-ku, Osaka 532, Japan
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Publication Date:
17 September 2002 (online)

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Various methyl 1,5-disubstituted imidazole-4-carboxylates are synthesized by the reaction of methyl 3-bromo-2-isocyanoacrylates with a variety of primary amines in the presence of triethylamine.

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