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Synthesis 1990; 1990(9): 845-846
DOI: 10.1055/s-1990-27032
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One-Pot Liquid-Phase Synthesis of DSIP and 5-Phe-DSIP Using Fluoren-9-yl-methoxycarbonyl-Protected Amino Acid Pentafluorophenyl Esters

Y. H. Wang* , J. C. Xu
  • *Department of Molecular Biology, Jilin University, Changchun, People's Republic of China and Division of Biochemistry, Shanghai Institute of Organic Chemistry, Academic Sinica, Shanghai, People's Republic of China
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Publication Date:
17 September 2002 (online)

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Fmoc-protected amino acid pentafluorophenyl esters are used in a one-pot liquid-phase synthesis of Delta Sleep-Inducing Peptide (DSIP) and 5-Phe-DSIP. Operational simplicity, fast performance high yield, and purity of product are advantages of this procedure which may represent an improved approach towards polypeptide synthesis.

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