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Synthesis 1990; 1990(12): 1173-1176
DOI: 10.1055/s-1990-27128
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A Novel Synthesis of α-Aminoaldehydes from Glyoxal Monoacetal

Alan R. Katritzky* , Joanna Borowiecka, Wei-Qiang Fan
  • *Department of Chemistry, University of Florida, Gainesville, FL 32611-2046, USA
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Publication Date:
02 May 2002 (online)

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Primary and secondary amines condense with benzotriazole and glyoxal monoacetal to give N-substituted 1-(benzotriazolyl)-2,2-diethoxyethylamines 4, which with Grignard reagents readily yield the corresponding 2-aminoalkanal diethylacetal 5. These are easily hydrolyzed to produce α-aminoaldehydes 6.

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