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Synlett 1992; 1992(6): 533-534
DOI: 10.1055/s-1992-21406
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Cytotoxic Alkaloids from Blue-Green Algae: A Total Synthesis of (-)-Didehydromirabazole A

Gerald Pattenden* , Stephen M. Thom
  • *Department of Chemistry, The University, Nottingham NG7 2RD, England
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Publication Date:
08 March 2002 (online)

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A concise total synthesis of the thiazole-thiazoline based metabolite (-)-didehydromirabazole A (2), a cytotoxic alkaloid isolated recently from the blue-green alga Scytonema mirabile, is described which uses sequential cyclocondensation reactions with methyl (R)-2-methylcysteine hydrochloride (5) as key steps, viz 6 → 7 and 10 → 11.

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