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Synlett 1994; 1994(2): 117-118
DOI: 10.1055/s-1994-22760
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A Succinct Asymmetric Synthesis of (2S,3R)-2-Methyl-3-aminopentanoic Acid Hydrochloride

Stephen G. Davies* , Osamu Ichihara, Iain A.S. Walters
  • *The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY, UK.
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Publication Date:
22 March 2002 (online)

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The highly stereoselective conjugate addition of lithium (R)-(α-methylbenzyl)benzylamide (R)-2 to tert-butyl (E)-2-methyl-2-pentenoate 3 affords a straightforward synthesis of (2S,3R)-2-methyl-3-aminopentanoic acid 1 as its hydrochloride salt 5.

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