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Synlett 1994; 1994(7): 555-556
DOI: 10.1055/s-1994-22927
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A Novel Synthesis of 4(3H)-Pteridinone Derivatives via Intermolecular Aza-Wittig Reaction

Tomohiro Okawa* , Shoji Eguchi
  • *Institute of Applied Organic Chemistry, Faculty of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-01, JAPAN
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Publication Date:
18 September 2002 (online)

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Aza-Wittig reaction of iminophosphorane 2, derived from methyl 3-aminopyrazine-2-carboxylate 1, with isocyanates followed by addition of alcohol or amine provided a novel synthetic route to 2,3-disubstituted 4(3H)-pteridinones.

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