The First Direct Synthesis of 2,4-Bis(methylthio)pyrimidines: Reaction of Ketones with Triflic Anhydride and Methyl Thiocyanate

A. García Martínez; A. Herrera Fernández; F. Moreno-Jiménez; M. J. Luengo Fraile; L. R. Subramanian

doi:10.1055/s-1994-22929

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Synlett 1994; 1994(7): 559-560
DOI: 10.1055/s-1994-22929

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The First Direct Synthesis of 2,4-Bis(methylthio)pyrimidines: Reaction of Ketones with Triflic Anhydride and Methyl Thiocyanate

A. García Martínez^* , A. Herrera Fernández, F. Moreno-Jiménez, M. J. Luengo Fraile, L. R. Subramanian

^*Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense, E-28040 Madrid, Spain.

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Publication Date:
18 September 2002 (online)

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The reaction of aliphatic and aromatic ketones 1 with triflic anhydride (Tf₂O) in the presence of methyl thiocyanate affords 2,4-bis(methylthio)pyrimidines 2 in good yields.

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