Synlett 1994; 1994(10): 814-816
DOI: 10.1055/s-1994-23013
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Regiospecific Enzymatic Hydroxylations of Pyrazinecarboxylic Acid and a Practical Synthesis of 5-Chloropyrazine-2-Carboxylic Acid

A. Kiener* , J. -P. Roduit, A. Tschech, A. Tinschert, K. Heinzmann
  • *Biotechnology and Chemistry Research Department, LONZA, CH-3930 Visp, Switzerland
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22. März 2002 (online)

Three different microorganisms capable of metabolizing pyridinecarboxylic acids were used for the regiospecific hydroxylation of all three ring carbon atoms of pyrazinecarboxylic acid to 3-hydroxy-5-hydroxy- or 6-hydroxypyrazine-2-carboxylic acid1. 5-Hydroxypyrazine-2-carboxylic acid was used for the preparation of 5-substituted pyrazine-2-carboxylic acids.