Synlett 1994; 1994(10): 829-830
DOI: 10.1055/s-1994-23020
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Lewis Acid-Catalyzed Intramolecular Reaction Between Silyl Enol Ethers and Ortho Esters: An Efficient Approach to 1,6-Anhydropyranoses

Serge Léger* , Jeff Omeara, Zhaoyin Wang
  • *Merck Frosst Centre for Therapeutic Research, P.O.Box 1005, Pointe Claire-Dorval, Québec, Canada H9R 4P8
Further Information

Publication History

Publication Date:
22 March 2002 (online)

Intramolecular cyclization of silyl enol ethers with ortho esters was studied under catalysis with various Lewis acids. Application of this methodology to cyclic ortho esters leads to the preparation of bicycloketones with the carbon skeleton of 1,6-anhydropyranose.