Synlett 1994; 1994(10): 842-844
DOI: 10.1055/s-1994-23025
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Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by A Drug-Unrelated Chiral Amino Thiol and the Corresponding Disulfide

Jahyo Kang* , Dong Soo Kim, Joo In Kim
  • *Department of Chemistry, Sogang University, Seoul 121-742, Korea
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22. März 2002 (online)

Reaction of diethylzinc with aldehydes in the presence of a catalytic amount of a ß-amino thiol 6 (5 mol %) and the corresponding disulfide 7 (2.5 mol %) in toluene at 0 °C provided the corresponding secondary alcohols in excellent ee's.