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Synthesis 1994; 1994(12): 1310-1312
DOI: 10.1055/s-1994-25686
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Synthesis of a 4′-Selenated 2-Deoxyadenosine Derivative: A Novel Precursor suitable for the Preparation of Modified Oligonucleotides

Bernd Giese* , Peter Erdmann, Thomas Schäfer, Urs Schwitter
  • *Department of Chemistry, University of Basel, St. Johanns Ring 19, CH-4056 Basel, Switzerland
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Publication Date:
25 April 2002 (online)

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Swern oxidation, subsequent selenation and reduction gave the selenated deoxyadenosine derivatives 4a and 4b. Isomer 4b as converted into the phosphoramidite 7, a building block for modified oligonucleotides 8.