Download PDF
Synlett 1995; 1995(9): 893-894
DOI: 10.1055/s-1995-5127
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Synthesis of (3S*,4R*)-Luffariolide

G. Hareau-Vittini, P. J. Kocienski*
  • *Department of Chemistry, The University, Southampton, SO17 1BJ, U.K., Fax +44 (01703) 593781; E-mail pjk1@soton.ac.uk
Further Information

Publication History

Publication Date:
31 December 2000 (online)

 PDF Download  Permissions and Reprints All articles of this category

A 1,2-metallate rearrangement of a higher order organocuprate was a key step in the synthesis of a trisubstituted alkene in the marine sesterterpenoid Luffariolide E. The synthesis shows that the stereochemistry of Luffariolides C, D, and E is (3S,4R).

sesterterpenoid - antitumour - radical cyclisation - 1,2-metallate rearrangement - higher order cuprate