Bryophyte Constituents; 7: New Synthesis of (+)-Rosmarinic Acid and Related Compounds

Theophil Eicher; Markus Ott; Andreas Speicher

doi:10.1055/s-1996-4289

Synthesis 1996; 1996(6): 755-762
DOI: 10.1055/s-1996-4289

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Bryophyte Constituents; 7: New Synthesis of (+)-Rosmarinic Acid and Related Compounds

Theophil Eicher¹ , Markus Ott, Andreas Speicher²

¹Fachbereich 11 Organische Chemie, Universität des Saarlandes, D-66041 Saarbrücken, Fax +49(681)3022409; E-mail: th.eicher@rz.uni-sb.de
²Fachbereich 11 Organische Chemie, Universität des Saarlandes, D-66041 Saarbrücken, Fax +49(681)3022409

Abstract

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Efficient and expeditious syntheses are described for rosmarinic acid (1) and its derivatives 2-4, making extensive use of allyl protective groups for both carboxylic acids and phenolic building blocks. (+)-(R)-Rosmarinic acid was obtained by a chemoenzymatic resolution of its phenyl lactic acid precursors.

bryophyte constituents - total synthesis - rosmarinic acid - allyl protective groups - chemoenzymatic resolution

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