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Synlett 1996; 1996(3): 209-211
DOI: 10.1055/s-1996-5383
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Two Complimentary Methods for the Synthesis of the Terminal N-Alkenyl-N-methylformamide Group Found in Cytotoxic Marine Macrolides

Ian Paterson* , Cameron Cowden, Christine Watson
  • *University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK
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Publication Date:
31 December 2000 (online)

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Two complimentary methods for the synthesis of trans-N-alkenyl-N-methylformamides from aldehydes are described. Method A involves condensation with MeNHCHO using P2O5, while Method B employs a Wittig reaction with 5 followed by I2-catalysed alkene isomerisation.

Wittig reaction - phosphorus pentoxide - N-methylformamide - condensation - scytophycin

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