Synlett 1996; 1996(5): 427-429
DOI: 10.1055/s-1996-5442
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Novel Tocopherol Derivatives V. The First Organometallic Derivative of Vitamin E

Thomas Rosenau, Wolf Dieter Habicher*
  • *Institut für Organische Chemie, TU Dresden, Mommsenstrasse 13, D-01062 Dresden, Germany, Fax: (49) 351 463 7030; Bitnet
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Publication History

Publication Date:
31 December 2000 (online)

The synthesis of O-trimethylsilyl-5a-α-tocopheryl magnesium bromide (α-tocopheryl Grignard compound), the first organometallic vitamin E derivative, is described. The products of the reaction between α-tocopheryl-Grignard and carbonyl compounds are strongly dependent on the conditions used in the hydrolysis of the magnesium salt intermediates. In addition, a simple and convenient method to determine the content of the organomagnesium reagent in reaction mixtures is presented.