New Improved Reagents for the Asymmetric Allylation of Ketones
31 December 2000 (online)
The synthesis of new 1,2-aminoalcohol derivatives 1b-d and 8a-h and their application in the stereoselective allylation of ethyl methyl ketones is described. The best results were obtained with the biphenyl derivative 8f, allowing the synthesis of tert-homoallylic ether 9f and 10f with a selectivity of 18:1.
Allylation - Allylsilane - Homoallylic alcohol - Ephedrin - TMSOTf