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Synlett 1996; 1996(5): 441-443
DOI: 10.1055/s-1996-5452
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A Practical Way to 2,5-Disubstituted Pyrrolidine Derivatives

Maria Vittoria Chiesa* , Leonardo Manzoni1 , Carlo Scolastico1
  • *Dipartimento di Chimica Organica e Industriale, Università di Milano, Centro per lo Studio delle Sostanze Organiche Naturali del C.N.R., via Venezian 21, I-20133 Milano
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Publication History

Publication Date:
31 December 2000 (online)

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A novel route for the synthesis of 2,5-disubstituted pyrrolidines has been found through the allylation with allyltributyltin of N-acyliminium ion derived from N-protected pyroglutamic acid tert-butyl ester.

Pyrrolidine - alkylation - acyliminium salt

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