Biocatalysis in Organic Synthesis 7. Enantioselective Transesterification Catalyzed by an Acylase: Remarkable Influence of Remote Substitution and the Nature of the Solvent on the Selectivity1
31 December 2000 (online)
Acylase I from Aspergillus species catalyzes the reaction of transesterification between vinyl acetate and racemic derivatives of 2-(hydroxymethyl)piperidine. It has been found that the enantioselectivity of the reaction depends on the solvent. Also it has been observed that remote substituents have a great influence on the enantioselectivity.
Acylase - enantioselective transesterification - amino alcohol - substituent effect - solvent effect