Download PDF
Synlett 1996; 1996(7): 693-694
DOI: 10.1055/s-1996-5544
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Effective Synthesis of α,α-Difluoro Ketones Using ACCUFLUOR TM - NFTh Fluorinating Reagent

Stojan Stavber* , Marko Zupan
  • *Laboratory for Organic and Bioorganic Chemistry, ”JoŽef Stefan” Institute and Department of Chemistry, University of Ljubljana, Jamova 39, 1000 Ljubljana, SLOVENIA, FAX: +386 61 219385
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Unsaturated cyclic α,α-difluoro ketones were prepared in high yield by the reaction of hydroxy-substituted aromatic derivatives with 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis-(tetrafluoroborate) [Accufluor TM - NFTh] in methanol or acetonitrile solution, while α,α-difluoro phenones were obtained from phenylsubstituted alkynes in MeCN/H2O 9:1 reaction media.

fluorination - 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis-(tetrafluoroborate) - α,α-difluoro ketones

      >