Synlett 1996; 1996(9): 909-910
DOI: 10.1055/s-1996-5590
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A Short Enantioselective Access to Pumiliotoxin 251D from L-Proline

Janine Cossy* , Manuel Cases, Domingo Gomez Pardo
  • *Laboratoire de Chimie Organique, Associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 - Paris Cedex 05, France, Fax: (33) 40 79 44 25
Further Information

Publication History

Publication Date:
31 December 2000 (online)

The indolizidine framework of pumiliotoxin 251D having the appropriate functionalities for incorporation of the tertiary hydroxyl group at the C-8 and the 2-alkylidene side chain at C-6 has been achieved from L-proline using a 6-exo-dig radical cyclisation.

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