Nucleophilic Reactions in the Pyrrole Series: Displacement of Halogen as a Tool to Functionalize the Pyrrole Nucleus

G. Cirrincione; A. M. Almerico; A. Passannanti; P. Diana; F. Mingoia

doi:10.1055/s-1997-1326

Synthesis 1997; 1997(10): 1169-1173
DOI: 10.1055/s-1997-1326

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Nucleophilic Reactions in the Pyrrole Series: Displacement of Halogen as a Tool to Functionalize the Pyrrole Nucleus

G. Cirrincione¹ , A. M. Almerico² , A. Passannanti² , P. Diana² , F. Mingoia³

¹Istituto Farmacochimico dell’Università, Via Archirafi 32, 90123 Palermo, Italy, Fax +39(91)6169999; E-mail: farmachim@mbox.unipa.it
²Istituto Farmacochimico dell’Università, Via Archirafi 32, 90123 Palermo, Italy
³Istituto di Chimica e Tecnologia die Prodotti Naturali-C.N.R., Via Archirafi 22-26, 90123 Palermo, Italy, Fax +39(91)6166281; E-mail: ictpn@ipacuc.cuc.unipa.it

Abstract

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Nucleophilic substitutions on halopyrroles by charged and neutral carbon, nitrogen, oxygen and sulfur nucleophiles are reported. Such reactions represent a valuable and versatile instrument to prepare a wide variety of functionalized pyrroles and to obtain building blocks for the synthesis of polycyclic systems.

nucleophilic substitutions - halopyrroles - carbon - nitrogen - oxygen and sulfur nucleophiles

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