Planta Medica, Inhaltsverzeichnis Planta Med 1999; 65(1): 043-046DOI: 10.1055/s-1999-13960 Original Paper Georg Thieme Verlag Stuttgart · New YorkAntiviral Tannins from Two Phyllanthus Species Karin C. S. Chen Liu1 , Mei-Tsu Lin1 , Shoei-Sheng Lee1 , Jwo-Farn Chiou2 , Shijun Ren3 , Eric J. Lien3 1School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, R. O. C. 2Department of Bacteriology, College of Medicine, National Taiwan University, Taipei, Taiwan, R. O. C. 3Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, U. S. A. Artikel empfehlen Abstract als PDF herunterladen(opens in new window) Artikel einzeln kaufen(opens in new window) Abstract: Seven ellagitannins isolated from Phyllanthus myrtifolius and P. urinaria (Euphorbiaceae) have been shown, for the first time, to be active against Epstein-Barr virus DNA polymerase (EBV-DP) at the μM level. All these compounds have the same moiety of a corilagin, and differ from each other by different substitutions at C-2 and C-4 of the glucose core. SAR analysis and molecular modeling reveal that the essential pharmacophore of these tannins resides in the corilagin moiety. The outer complex carboxylic acid moieties appear to act only as auxopharmacore. Key words: Phyllanthus myrtifolius - P. urinaria - Euphorbiaceae - Tannins - EBV DNA polymerase - SAR - pharmacophore PDF (132 kb)
