Abstract:
Bioactivity-directed fractionation of the MeOH extract of the stem barks
of Rollinia emarginata resulted in the isolation
of six compounds, four acetogenins, rolliniastatin-1, sylvaticin, squamocin,
and rollidecin B, one lignan, lirioresinol B, and an oxoaporphine, liriodenin.
Their structures were determined by spectroscopic analysis and their
in vitro leishmanicidal and trypanocidal properties are reported.
Key words:
Rollinia emarginata Schldl. - Annonaceae - acetogenins -
Leishmania
-
Trypanosoma cruzi
- Leishmanicidal - trypanocidal
