Planta Medica, Inhaltsverzeichnis Planta Med 1999; 65(4): 320-324DOI: 10.1055/s-1999-13994 PapersPharmacology© Georg Thieme Verlag Stuttgart · New YorkEffect of Several Sesquiterpene Lactones on Lipid Peroxidation and Glutathione LevelJadwiga Jodynis-Liebert1 , Marek Murias1 , Elżbieta Błoszyk2 1Department of Toxicology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland 2Department of Medical Plants, Karol Marcinkowski University of Medical Sciences, Poznań, Poland Artikel empfehlen Abstract als PDF herunterladen(opens in new window) Artikel einzeln kaufen(opens in new window) Abstract Seven sesquiterpene lactones isolated from Helenium aromaticum: helenalin, mexicanin I, linifolin A, geigerinin, and from Telekia speciosa: 6α-hydroxy-2,3-dihydroaromaticin, asperilin, telekin have been tested for their hydroxyl radical scavenging activity and effect on lipid peroxidation. All compounds were found to be potent hydroxyl radical scavengers but did not affect lipid peroxidation in vitro. In vivo they exerted pro-oxidative properties and caused glutathione level depletion and elevation in glutathione peroxidase activity. Key words Sesquiterpene lactones - Helenium aromaticum - Telekia speciosa - Compositae - lipid peroxidation - hydroxyl radical scavenging - glutathione depletion PDF (82 kb)
