The metabolism of fluoresceinyl isothiocyanate labeled aloemannan (FITC-AM) was examined
by p.o. and i.v. administration in mice at a dose of 120 mg/kg. Analysis of FITC-AM in urine and feces
showed that FITC-AM (MW 500 KD) was metabolized into smaller molecules that mainly
accumulated in the kidneys. AM was catabolized by the human intestinal microflora
to catabolites 1 and 2 with molecular weights of 30 and 10 KD, respectively. Hydrolysis of AM showed hexosamine
peaks on HPAE. The findings suggest that the immunomodulation of AM may come from
not only neutral polysaccharides but also contaminated hexosamine in AM.
Aloemannan -
Aloe barbadensis
- Asphodelaceae - fluoresceinyl isothiocyanate aloemannan - metabolism - catabolites
- intestinal microflora
